Original Research

Sepsis Presenting in Hospitals versus Emergency Departments: Demographic, Resuscitation, and Outcome Patterns in a Multicenter Retrospective Cohort


BACKGROUND: Differences between hospital-presenting sepsis (HPS) and emergency department-presenting sepsis (EDPS) are not well described.
OBJECTIVES: We aimed to (1) quantify the prevalence of HPS versus EDPS cases and outcomes; (2) compare HPS versus EDPS characteristics at presentation; (3) compare HPS versus EDPS in process and patient outcomes; and (4) estimate risk differences in patient outcomes attributable to initial resuscitation disparities.
DESIGN: Retrospective consecutive-sample cohort.
SETTING: Nine hospitals from October 1, 2014, to March 31, 2016.
PATIENTS: All hospitalized patients with sepsis or septic shock, as defined by simultaneous (1) infection, (2) ≥2 Systemic Inflammatory Response Syndrome (SIRS) criteria, and (3) ≥1 acute organ dysfunction criterion. EDPS met inclusion criteria while physically in the emergency department (ED). HPS met the criteria after leaving the ED.
MEASUREMENTS: We assessed overall HPS versus EDPS contributions to case prevalence and outcomes, and then compared group differences. Process outcomes included 3-hour bundle compliance and discrete bundle elements (eg, time to antibiotics). The primary patient outcome was hospital mortality.
RESULTS: Of 11,182 sepsis hospitalizations, 2,509 (22.4%) were hospital-presenting. HPS contributed 785 (35%) sepsis mortalities. HPS had more frequent heart failure (OR: 1.31, CI: 1.18-1.47), renal failure (OR: 1.62, CI: 1.38-1.91), gastrointestinal source of infection (OR: 1.84, CI: 1.48-2.29), euthermia (OR: 1.45, CI: 1.10-1.92), hypotension (OR: 1.85, CI: 1.65-2.08), or impaired gas exchange (OR: 2.46, CI: 1.43-4.24). HPS were admitted less often from skilled nursing facilities (OR: 0.44, CI: 0.32-0.60), had chronic obstructive pulmonary disease (OR: 0.53, CI: 0.36-0.78), tachypnea (OR: 0.76, CI: 0.58-0.98), or acute kidney injury (OR: 0.82, CI: 0.68-0.97). In a propensity-matched cohort (n = 3,844), HPS patients had less than half the odds of 3-hour bundle compliant care (17.0% vs 30.3%, OR: 0.47, CI: 0.40-0.57) or antibiotics within three hours (66.2% vs 83.8%, OR: 0.38, CI: 0.32-0.44) vs EDPS. HPS was associated with higher mortality (31.2% vs 19.3%, OR: 1.90, CI: 1.64-2.20); 23.3% of this association was attributable to differences in initial resuscitation (resuscitation-adjusted OR: 1.69, CI: 1.43-2.00).
CONCLUSIONS: HPS differed from EDPS by admission source, comorbidities, and clinical presentation. These patients received markedly less timely initial resuscitation; this disparity explained a moderate proportion of mortality differences.

© 2019 Society of Hospital Medicine

Sepsis is both the most expensive condition treated and the most common cause of death in hospitals in the United States.1-3 Most sepsis patients (as many as 80% to 90%) meet sepsis criteria on hospital arrival, but mortality and costs are higher when meeting criteria after admission.3-6 Mechanisms of this increased mortality for these distinct populations are not well explored. Patients who present septic in the emergency department (ED) and patients who present as inpatients likely present very different challenges for recognition, treatment, and monitoring.7 Yet, how these groups differ by demographic and clinical characteristics, the etiology and severity of infection, and patterns of resuscitation care are not well described. Literature on sepsis epidemiology on hospital wards is particularly limited.8

This knowledge gap is important. If hospital-presenting sepsis (HPS) contributes disproportionately to disease burdCHFens, it reflects a high-yield population deserving the focus of quality improvement (QI) initiatives. If specific causes of disparities were identified—eg, poor initial resuscitation— they could be specifically targeted for correction. Given that current treatment guidelines are uniform for the two populations,9,10 characterizing phenotypic differences could also have implications for both diagnostic and therapeutic recommendations, particularly if the groups display substantially differing clinical presentations. Our prior work has not probed these effects specifically, but suggested ED versus inpatient setting at the time of initial sepsis presentation might be an effect modifier for the association between several elements of fluid resuscitation and patient outcomes.11,12

We, therefore, conducted a retrospective analysis to ask four sequential questions: (1) Do patients with HPS, compared with EDPS, contribute adverse outcome out of proportion to case prevalence? (2) At the time of initial presentation, how do HPS patients differ from EDPS patients with respect to demographics, comorbidities, infectious etiologies, clinical presentations, and severity of illness (3) If holding observed baseline factors constant, does the physical location of sepsis presentation inherently increase the risk for treatment delays and mortality? (4) To what extent can differences in the likelihood for timely initial treatment between the ED and inpatient settings explain differences in mortality and patient outcomes?

We hypothesized a priori that HPS would reflect chronically sicker patients whom both received less timely resuscitation and who contributed disproportionately frequent bad outcomes. We expected disparities in timely resuscitation care would explain a large proportion of this difference.


We performed a retrospective analysis of the Northwell Sepsis Database, a prospectively captured, multisite, real world, consecutive-sample cohort of all “severe sepsis” and septic shock patients treated at nine tertiary and community hospitals in New York from October 1, 2014, to March 31, 2016. We analyzed all patients from a previously published cohort.11

Database Design and Structure

The Northwell Sepsis Database has previously been described in detail.11,13,14 Briefly, all patients met clinical sepsis criteria: (1) infection AND (2) ≥2 (SIRS) criteria AND (3) ≥1 acute organ dysfunction criterion. Organ dysfunction criteria were hypotension, acute kidney injury (AKI), coagulopathy, altered gas exchange, elevated bilirubin (≥2.0 mg/dL), or altered mental status (AMS; clarified in Supplemental Table 1). All organ dysfunction was not otherwise explained by patients’ medical histories; eg, patients on warfarin anticoagulation were not documented to have coagulopathy based on international normalized ratio > 1.5. The time of the sepsis episode (and database inclusion) was the time of the first vital sign measurement or laboratory result where a patient simultaneously met all three inclusion criteria: infection, SIRS, and organ dysfunction. The database excludes patients who were <18 years, declined bundle interventions, had advance directives precluding interventions, or were admitted directly to palliative care or hospice. Abstractors assumed comorbidities were absent if not documented within the medical record and that physiologic abnormalities were absent if not measured by the treatment team. There were no missing data for the variables analyzed. We report analysis in adherence with the STROBE statement guidelines for observational research.


The primary exposure was whether patients had EDPS versus HPS. We defined EDPS patients as meeting all objective clinical inclusion criteria while physically in the ED. We defined HPS as first meeting sepsis inclusion criteria outside the ED, regardless of the reason for admission, and regardless of whether patients were admitted through the ED or directly to the hospital. All ED patients were admitted to the hospital.


Process outcomes were full 3-hour bundle compliance, time to antibiotic administration, blood cultures before antibiotics, time to fluid initiation, the volume of administered fluid resuscitation, lactate result time, and whether repeat lactate was obtained (Supplemental Table 2). Treatment times were times of administration (rather than order time). The primary patient outcome was hospital mortality. Secondary patient outcomes were mechanical ventilation, ICU admission, ICU days, hospital length of stay (LOS). We discounted HPS patients’ LOS to include only days after meeting the inclusion criteria. Patients were excluded from the analysis of the ICU admission outcome if they were already in the ICU prior to meeting sepsis criteria.

Statistical Analysis

We report continuous variables as means (standard deviation) or medians (interquartile range), and categorical variables as frequencies (proportions), as appropriate. Summative statistics with 95% confidence intervals (CI) describe overall group contributions. We used generalized linear models to determine patient factors associated with EDPS versus HPS, entering random effects for individual study sites to control for intercenter variability.

Next, to generate a propensity-matched cohort, we computed propensity scores adjusted from a priori selected variables: age, sex, tertiary versus community hospital, congestive heart failure (CHF), renal failure, COPD, diabetes, liver failure, immunocompromise, primary source of infection, nosocomial source, temperature, initial lactate, presenting hypotension, altered gas exchange, AMS, AKI, and coagulopathy. We then matched subjects 1:1 without optimization or replacement, imposing a caliper width of 0.01; ie, we required matched pairs to have a <1.0% difference in propensity scores. The macro used to match subjects is publically available.15

We then compared resuscitation and patient outcomes in the matched cohort using generalized linear models, ie, doubly-robust estimation (DRE).16 When assessing patient outcomes corrected for resuscitation, we used mixed DRE/multivariable regression. We did this for two reasons: first, DRE has the advantage of only requiring only one approach (propensity vs covariate adjustments) to be correctly specified.16 Second, computing propensity scores adjusted for resuscitation would be inappropriate given that resuscitation occurs after the exposure allocation (HPS vs EDPS). However, these factors could still impact the outcome and in fact, we hypothesized they were potential mediators of the exposure effect. To interrogate this mediating relationship, we recapitulated the DRE modeling but added covariates for resuscitation factors. Resuscitation-adjusted models controlled for timeliness of antibiotics, fluids, and lactate results; blood cultures before antibiotics; repeat lactate obtained, and fluid volume in the first six hours. Since ICU days and LOS are subject to competing risks bias (LOS could be shorter if patients died earlier), we used proportional hazards models where “the event” was defined as a live discharge to censor for mortality and we report output as inverse hazard ratios. We also tested interaction coefficients for discrete bundle elements and HPS to determine if specific bundle elements were effect modifiers for the association between the presenting location and mortality risk. Finally, we estimated attributable risk differences by comparing adjusted odds ratios of adverse outcome with and without adjustment for resuscitation variables, as described by Sahai et al.17

As sensitivity analyses, we recomputed propensity scores and generated a new matched cohort that excluded HPS patients who met criteria for sepsis while already in the ICU for another reason (ie, excluding ICU-presenting sepsis). We then recapitulated all analyses as above for this cohort. We performed analyses using SAS version 9.4 (SAS Institute, Cary, North Carolina).


Prevalence and Outcome Contributions

Of the 11,182 sepsis patients in the database, we classified 2,509 (22%) as HPS (Figure 1). HPS contributed 785 (35%) of 2,241 sepsis-related mortalities, 1,241 (38%) mechanical ventilations, and 1,762 (34%) ICU admissions. Of 39,263 total ICU days and 127,178 hospital days, HPS contributed 18,104 (46.1%) and 44,412 (34.9%) days, respectively.

Patient Characteristics

Most HPS presented early in the hospital course, with 1,352 (53.9%) cases meeting study criteria within three days of admission. Median time from admission to meeting study criteria for HPS was two days (interquartile range: one to seven days). We report selected baseline patient characteristics in Table 1 and adjusted associations of baseline variables with HPS versus EDPS in Table 2. The full cohort characterization is available in Supplemental Table 3. Notably, HPS patients more often had CHF (aOR [adjusted odds ratio}: 1.31, CI: 1.18-1.47) or renal failure (aOR: 1.62, CI: 1.38-1.91), gastrointestinal source of infection (aOR: 1.84, CI: 1.48-2.29), hypothermia (aOR: 1.56, CI: 1.28-1.90) hypotension (aOR: 1.85, CI: 1.65-2.08), or altered gas exchange (aOR: 2.46, CI: 1.43-4.24). In contrast, HPS patients less frequently were admitted from skilled nursing facilities (aOR: 0.44, CI: 0.32-0.60), or had COPD (aOR: 0.53, CI: 0.36-0.76), fever (aOR: 0.70, CI: 0.52-0.91), tachypnea (aOR: 0.76, CI: 0.58-0.98), or AKI (aOR: 082, CI: 0.68-0.97). Other baseline variables were similar, including respiratory source, tachycardia, white cell abnormalities, AMS, and coagulopathies. These associations were preserved in the sensitivity analysis excluding ICU-presenting sepsis.

Propensity Matching

Propensity score matching yielded 1,942 matched pairs (n = 3,884, 77% of HPS patients, 22% of EDPS patients). Table 1 and Supplemental Table 3 show patient characteristics after propensity matching. Supplemental Table 4 shows the propensity model. The frequency densities are shown for the cohort as a function of propensity score in Supplemental Figure 1. After matching, frequencies between groups differed by <5% for all categorical variables assessed. In the sensitivity analysis, propensity matching (model in Supplemental Table 5) resulted in 1,233 matched pairs (n = 2,466, 49% of HPS patients, 14% of EDPS patients), with group differences comparable to the primary analysis.

Process Outcomes

We present propensity-matched differences in initial resuscitation in Figure 2A for all HPS patients, as well as non-ICU-presenting HPS, versus EDPS. HPS patients were roughly half as likely to receive fully 3-hour bundle compliant care (17.0% vs 30.3%, aOR: 0.47, CI: 0.40-0.57), to have blood cultures drawn within three hours prior to antibiotics (44.9% vs 67.2%, aOR: 0.40, CI: 0.35-0.46), or to receive fluid resuscitation initiated within two hours (11.1% vs 26.1%, aOR: 0.35, CI: 0.29-0.42). Antibiotic receipt within one hour was comparable (45.3% vs 48.1%, aOR: 0.89, CI: 0.79-1.01). However, differences emerged for antibiotics within three hours (66.2% vs 83.8%, aOR: 0.38, CI: 0.32-0.44) and persisted at six hours (77.0% vs 92.5%, aOR: 0.27, CI: 0.22-33). Excluding ICU-presenting sepsis from propensity matching exaggerated disparities in antibiotic receipt at one hour (43.4% vs 49.1%, aOR: 0.80, CI: 0.68-0.93), three hours (64.2% vs 86.1%, aOR: 0.29, CI: 0.24-0.35), and six hours (75.7% vs 93.0%, aOR: 0.23, CI: 0.18-0.30). HPS patients more frequently had repeat lactate obtained within 24 hours (62.4% vs 54.3%, aOR: 1.40, CI: 1.23-1.59).

Patient Outcomes

HPS patients had higher mortality (31.2% vs19.3%), mechanical ventilation (51.5% vs27.4%), and ICU admission (60.6% vs 46.5%) (Table 1 and Supplemental Table 6). Figure 2b shows propensity-matched and covariate-adjusted differences in patient outcomes before and after adjusting for initial resuscitation. aORs corresponded to approximate relative risk differences18 of 1.38 (CI: 1.28-1.48), 1.68 (CI: 1.57-1.79), and 1.72 (CI: 1.61-1.84) for mortality, mechanical ventilation, and ICU admission, respectively. HPS was associated with 83% longer mortality-censored ICU stays (five vs nine days, HR–1: 1.83, CI: 1.65-2.03), and 108% longer hospital stay (eight vs 17 days, HR–1: 2.08, CI: 1.93-2.24). After adjustment for resuscitation, all effect sizes decreased but persisted. The initial crystalloid volume was a significant negative effect modifier for mortality (Supplemental Table 7). That is, the magnitude of the association between HPS and greater mortality decreased by a factor of 0.89 per 10 mL/kg given (CI: 0.82-0.97). We did not observe significant interaction from other interventions, or overall bundle compliance, meaning these interventions’ association with mortality did not significantly differ between HPS versus EDPS.

The implied attributable risk difference from discrepancies in initial resuscitation was 23.3% for mortality, 35.2% for mechanical ventilation, and 7.6% for ICU admission (Figure 2B). Resuscitation explained 26.5% of longer ICU LOS and 16.7% of longer hospital LOS associated with HPS.

Figure 2C shows sensitivity analysis excluding ICU-presenting sepsis from propensity matching (ie, limiting HPS to hospital ward presentations). Again, HPS was associated with all adverse outcomes, though effect sizes were smaller than in the primary cohort for all outcomes except hospital LOS. In this cohort, resuscitation factors now explained 16.5% of HPS’ association with mortality, and 14.5% of the association with longer ICU LOS. However, they explained a greater proportion (13.0%) of ICU admissions. Attributable risk differences were comparable to the primary cohort for mechanical ventilation (37.6%) and hospital LOS (15.3%).


In this analysis of 11,182 sepsis and septic shock patients, HPS contributed 22% of prevalence but >35% of total sepsis mortalities, ICU utilization, and hospital days. HPS patients had higher comorbidity burdens and had clinical presentations less obviously attributable to infection with more severe organ dysfunction. EDPS received antibiotics within three hours about 1.62 times more often than do HPS patients. EDPS patients also receive fluids initiated within two hours about 1.82 times more often than HPS patients do. HPS had nearly 1.5-fold greater mortality and LOS, and nearly two-fold greater mechanical ventilation and ICU utilization. Resuscitation disparities could partially explain these associations. These patterns persisted when comparing only wards presenting HPS with EDPS.

Our analysis revealed several notable findings. First, these data confirm that HPS represents a potentially high-impact target population that contributes adverse outcomes disproportionately frequently with respect to case prevalence.

Our findings, unsurprisingly, revealed HPS and EDPS reflect dramatically different patient populations. We found that the two groups significantly differed by the majority of the baseline factors we compared. It may be worth asking if and how these substantial differences in illness etiology, chronic health, and acute physiology impact what we consider an optimal approach to management. Significant interaction effects of fluid volume on the association between HPS and mortality suggest differential treatment effects may exist between patients. Indeed, patients who newly arrive from the community and those who are several days into admission likely have different volume status. However, no interactions were noted with other bundle elements, such as timeliness of antibiotics or timeliness of initial fluids.

Another potentially concerning observation was that HPS patients were admitted much less frequently from skilled nursing facilities, as it could imply that this poorer-fairing population had a comparatively higher baseline functional status. The fact that 25% of EDPS cases were admitted from these facilities also underscores the need to engage skilled nursing facility providers in future sepsis initiatives.

We found marked disparities in resuscitation. Timely delivery of interventions, such as antibiotics and initial fluid resuscitation, occurred less than half as often for HPS, especially on hospital wards. While evidence supporting the efficacy of specific 3-hour bundle elements remains unsettled,19 a wealth of literature demonstrates a correlation between bundle uptake and decreased sepsis mortality, especially for early antibiotic administration.13,20-26 Some analysis suggests that differing initial resuscitation practices explain different mortality rates in the early goal-directed therapy trials.27 The comparatively poor performance for non-ICU HPS indicates further QI efforts are better focused on inpatient wards, rather than on EDs or ICUs where resuscitation is already delivered with substantially greater fidelity.

While resuscitation differences partially explained outcome discrepancies between groups, they did not account for as much variation as expected. Though resuscitation accounted for >35% of attributable mechanical ventilation risk, it explained only 16.5% of mortality differences for non-ICU HPS vs EDPS. We speculate that several factors may contribute.

First, HPS patients are already hospitalized for another acute insult and may be too physiologically brittle to derive equal benefit from initial resuscitation. Some literature suggests protocolized sepsis resuscitation may paradoxically be more effective in milder/earlier disease.28

Second, clinical information indicating septic organ dysfunction may become available too late in HPS—a possible data limitation where inpatient providers are counterintuitively more likely to miss early signs of patients’ deterioration and a subsequent therapeutic window. Several studies found that fluid resuscitation is associated with improved sepsis outcomes only when it is administered very early.11,29-31 In inpatient wards, decreased monitoring32 and human factors (eg, hospital workflow, provider-to-patient ratios, electronic documentation burdens)33,34 may hinder early diagnosis. In contrast, ED environments are explicitly designed to identify acutely ill patients and deliver intervention rapidly. If HPS patients were sicker when they were identified, this would also explain their more severe organ dysfunctions. Our data seems to support this possibility. HPS patients had tachypnea less frequently but more often had impaired gas exchange. This finding may suggest that early tachypnea was either less often detected or documented, or that it had progressed further by the time of detection.

Third, inpatients with sepsis may more often present with greater diagnostic complexity. We observed that HPS patients were more often euthermic and less often tachypneic. Beyond suggesting a greater diagnostic challenge, this also raises questions as to whether differences reflect patient physiology (response to infection) or iatrogenic factors (eg, prior antipyretics). Higher comorbidity and acute physiological burdens also limit the degree to which new organ dysfunction can be clearly attributed to infection. We note differences in the proportion of patients who received antibiotics increased over time, suggesting that HPS patients who received delayed antibiotics did so much later than their EDPS counterparts. This lag could also arise from diagnostic difficulty.

All three possibilities highlight a potential lead time effect, where the same measured three-hour period on the wards, between meeting sepsis criteria and starting treatment, actually reflects a longer period between (as yet unmeasurable) pathobiologic “time zero” and treatment versus the ED. The time of sepsis detection, as distinct from the time of sepsis onset, therefore proves difficult to evaluate and impossible to account for statistically.

Regardless, our findings suggest additional difficulty in both the recognition and resuscitation of inpatient sepsis. Inpatients, especially with infections, may need closer monitoring. How to cost effectively implement this monitoring is a challenge that deserves attention.

A more rational systems approach to HPS likely combines efforts to improve initial resuscitation with other initiatives aimed at both improving monitoring and preventing infection.

To be clear, we do not imply that timely initial resuscitation does not matter on the wards. Rather, resuscitation-focused QI alone does not appear to be sufficient to overcome differences in outcomes for HPS. The 23.3% attributable mortality risk we observed still implies that resuscitation differences could explain nearly one in four excess HPS mortalities. We previously showed that timely resuscitation is strongly associated with better outcomes.11,13,30 As discussed above, the unclear degree to which better resuscitation is a marker for more obvious presentations is a persistent limitation of prior investigations and the present study.

Taken together, the ultimate question that this study raises but cannot answer is whether the timely recognition of sepsis, rather than any specific treatment, is what truly improves outcomes.

In addition to those above, this study has several limitations. Our study did not differentiate HPS with respect to patients admitted for noninfectious reasons and who subsequently became septic versus nonseptic patients admitted for an infection who subsequently became septic from that infection. Nor could we discriminate between missed ED diagnoses and true delayed presentations. We note distinguishing these entities clinically can be equally challenging. Additionally, this was a propensity-matched retrospective analysis of an existing sepsis cohort, and the many limitations of both retrospective study and propensity matching apply.35,36 We note that randomizing patients to develop sepsis in the community versus hospital is not feasible and that two of our aims intended to describe overall patterns rather than causal effects. We could not ascertain robust measures of severity of illness (eg, SOFA) because a real world setting precludes required data points—eg, urine output is unreliably recorded. We also note incomplete overlap between inclusion criteria and either Sepsis-2 or -3 definitions,1,37 because we designed and populated our database prior to publication of Sepsis-3. Further, we could not account for surgical source control, the appropriateness of antimicrobial therapy, mechanical ventilation before sepsis onset, or most treatments given after initial resuscitation.

In conclusion, hospital-presenting sepsis accounted for adverse patient outcomes disproportionately to prevalence. HPS patients had more complex presentations, received timely antibiotics half as often ED-presenting sepsis, and had nearly twice the mortality odds. Resuscitation disparities explained roughly 25% of this difference.


The authors have no conflicts of interest to disclose.


This investigation was funded in part by a grant from the Center for Medicare and Medicaid Innovation to the High Value Healthcare Collaborative, of which the study sites’ umbrella health system was a part. This grant helped fund the underlying QI program and database in this study.


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